Monday, November 18, 2013

CRISPR: Genetic Engineering Gets Real

Steve Hsu reports on a technique I first heard of in my MOOC course in Molecular Biology from Eric Lander.  It hints at the possibility of molecular manipulation of genes on very fine scale.

Professor Dagan Wells, an IVF researcher at Oxford University, said that although there is still a long way to go before CRISPR could even be considered for use on IVF embryos, the technique could overcome many of the objections to permanently altering the germline of families affected by inherited disorders

“If the new method is as precise as has been suggested then concerns about inducing inadvertent, detrimental changes to the genome might start to subside. In that case, permanently fixing a lethal genetic defect might not seem so controversial,” Professor Wells said.

“However, I'm sure there will be some concern about the possibility that the technology could be used for 'enhancement' rather than repair, veering from medicine towards eugenics,” he warned. ...